Carboplatin Injections Method
There are many ways to cure cancer disease and one of the best technique employed to cure cancer is chemotherapy. The anti cancer drugs injected into the body, the drug spreads over the body and destroy the effected cancer cells. Generally In Chemotherapy doctors employs many drugs for treatment among them most doctors recommend to use Carboplatin chemotherapy injection method.
Chemotherapy treatment is classified into many types where the Carboplatin drug medication belongs to the alkylating agent group. Carboplatin used for ovarian cancer, But also used in the treatments of lung, neck, head, abdominal, bladder, breast cancers too.
Carboplatin injections drug will pass through the body with help of an injection directly into the abdominal peritoneal cavity. The medical practitioner who chooses the amount of drug to be used depends on age, health and stage of cancer.
The side effects produced by using this type of chemotherapy will disappear after the treatment is over. General symptoms found during the usage of this drug are Hair loss, vomiting, low blood counts, taste changes and weakness.
Patient has to contact medical practitioner if he experiences any side effects as a result of the Carboplatin chemotherapy method.
patient experiences high fever, difficulty in breathing, chest pain, unusual bleeding, diarrhea, muscle cramps, abdominal pain and extreme fatigue. then he has to rush to the nearby hospital to consult a physician.
Before subjecting to the Carboplatin chemotherapy method, the patients have to clear it out with the physician about the medications they have been taking so far, and what they are allergic to.
Carboplatin Injection, 50 mg/5 mL, 150 mg/15 mL and 450 mg/45 mL.
Dosage and administration
Aluminum reacts with carboplatin causing precipitate formation, where needles containing aluminum parts which may come in contact with the drug must not be used.
Carboplatin Injection, as a single agent shown to be effective in patients with recurrent ovarian carcinoma at 360 mg/m2 IV dosage on day 1 every 4 weeks.
Single intermittent courses of Carboplatin will not be repeated until the neutrophil count is at least 2,000 and the platelet count is at least 100,000.
In the chemotherapy of advanced ovarian cancer, an effective combination for previously untreated patients consists of:
Carboplatin is usually administered by an infusion lasting 15 minutes or longer. No pre- or post-treatment hydration or forced diuresis is required.
Patients with Impaired Kidney Function
Patients with creatinine clearance values below 60 mL/min have maximum risk of severe bone marrow suppression. Renally-impaired patients who received single-agent carboplatin therapy, the incidence of severe leukopenia, neutropenia, or thrombocytopenia was been about 25% when the dosage modifications has been used.
Indications and usage:
For the treatment of advanced ovarian carcinoma of epithelial origin. The recommended dosage for previously untreated adults (normal renal function) is 400mg/m² as a single intravenous infusion over 15-60 minutes.
Therapy should not be repeated until four weeks, patients with risk factors such as previous myelo suppressive therapy or in the aged, the initial dosage may need to be reduced to 20-25%. Determination of the haematological nadir by weekly blood counts is recommended for adjusting future doses and scheduling of carboplatin.